GROUP LEADER:
Fátima Gebauer
LAB MANAGERS:
Olga Coll, Tanit Guitart
POSTDOCTORAL RESEARCHERS:
Santiago Guerrero
PhD STUDENTS:
Himapriyanka Nadimpali, Marta Inglés, Roísin-Ana Ni Charthaigh, Alberto Indacochea, Neus Mestre
MASTER STUDENT:
Adriá Nogales
TECHNICIAN:
Anna Ribó
Our group is interested in post-transcriptional regulation during embryo development and disease. In particular, we investigate how RNA-binding proteins (RBPs) regulate translation and how this is connected with general cell homeostasis and cancer progression. During this year, we have identified new RBPs with roles in melanoma progression, and are currently investigating their molecular mechanisms of action. In collaborative work, we have also contributed to expand the roles of the RBP UNR/CSDE1 in preventing stem cell differentiation, and have evaluated its potential as a biomarker for pancreatic cancer outcome.
Ju Lee H, Bartsch D, Xiao C, Guerrero S, Ahuja G, Schindler C, Moresco JJ, Yates JR 3rd, Gebauer F, Bazzi H, Dieterich C, Kurian L, Vilchez D.
“A post-transcriptional program coordinated by CSDE1 prevents 2 intrinsic neural differentiation of human embryonic stem cells.”
Nat. Commun, 8:1456 (2017).
Martinez-Useros J, Georgiev-Hristov T, Fernández-Aceñero MJ, Borrero-Palacios A, Indacochea A, Guerrero S, Li W, Cebrián A, Gómez Del Pulgar T, Puime-Otin A, Del Puerto-Nevado L, Rodríguez-Remírez M, Pérez N, Celdrán A, Gebauer F, Garcia-Foncillas J.
“UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept.”
PLoS One, 12(8):e0182044 (2017).
