GROUP LEADER:
Tomas Marquès-Bonet, ICREA Research Professor
POSTDOCTORAL FELLOWS:
Inna Povolotskaya, Martin Kuhlwilm, David deJuan.
PhD STUDENTS:
Raquel Garcia, Jessica Hernández, Marc de Manuel, Irene Lobon, Lukas Kuderna, Claudia Fontsere, Aitor Serres, Sojung Han, Manuel Solís, Luis Ferrández
Our main line of research is centered in the discovery of the extent of all kinds of genome variation within different phenotypically genomes. Specifically, we study genome variation (centered on CNVs), gene expression and epigenetic differences in the human species in the context of great ape evolution and other mammalian genomes such as canids. The goal is to create an integrated view of genome evolution by studying changes in the composition, frequency, size and location at every major branch point of recent human evolution.
Solis-Moruno M, de Manuel M, Hernandez-Rodriguez J, Fontsere C, Gomara-Castaño A, Valsera-Naranjo C, Crailsheim D, Navarro A, Llorente M, Riera L, Feliu-Olleta O, Marques-Bonet T.
“Potential damaging mutation in LRP5 from genome sequencing of the first reported chimpanzee with the Chiari malformation.”
Sci Rep, 7(1):15224 (2017).
Hernandez-Rodriguez J, Arandjelovic M, Lester J, de Filippo C, Weihmann A, Meyer M, Angedakin S, Casals F, Navarro A, Vigilant L, Kühl HS, Langergraber K, Boesch C, Hughes D, Marques-Bonet T.
“The impact of endogenous content, replicates and pooling on genome capture from fecal samples.”
Mol Ecol Resour, 18(2):319-333 (2017).
Kuderna LFK, Tomlinson C, Hillier LW, Tran A, Fiddes I, Armstrong J, Laayouni H, Gordon D, Huddleston J, Perez RG, Povolotskaya I, Armero AS, Garrido JG, Ho D, Ribeca P, Alioto T, Green RE, Paten B, Navarro A, Betranpetit J, Herrero J, Eichler EE, Sharp AJ, Feuk L, Warren WC, Marques-Bonet T
“A 3-way hybrid approach to generate a new high quality chimpanzee reference genome (Pan_tro_3.0).”
Gigascience, 6(11):1-6 (2017).
McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network (including Tomas Marques-Bonet).
“Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network.”
Science, 356(6336) (2017).
Librado P, Gamba C, Gaunitz C, Der Sarkissian C, Pruvost M, Albrechtsen A, Fages A, Khan N, Schubert M, Jagannathan V, Serres-Armero A, Kuderna LFK, Povolotskaya IS, Seguin-Orlando A, Lepetz S, Neuditschko M, Thèves C, Alquraishi S, Alfarhan AH, Al-Rasheid K, Rieder S, Samashev Z, Francfort HP, Benecke N, Hofreiter M, Ludwig A, Keyser C, Marques-Bonet T, Ludes B, Crubézy E, Leeb T, Willerslev E, Orlando L.
“Ancient genomic changes associated with domestication of the horse.”
Science, 356(6336):442-445 (2017).
